منابع مشابه
Genome-wide association studies with high-dimensional phenotypes.
High-dimensional phenotypes hold promise for richer findings in association studies, but testing of several phenotype traits aggravates the grand challenge of association studies, that of multiple testing. Several methods have recently been proposed for testing jointly all traits in a high-dimensional vector of phenotypes, with prospect of increased power to detect small effects that would be m...
متن کاملMethods for Analyzing Multivariate Phenotypes in Genetic Association Studies.
This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Multivariate phenotypes are frequently encountered in genetic association studies. The purpose of analyzing multivariate phenotypes usually includes discovery of novel genetic varian...
متن کاملAssociation of Haptoglobin Phenotypes with Serum Levels of IgE and IgA in Allergic Rhinitis Patients
Background: Allergic rhinitis (AR) is an allergic disorder of the nasal tissue that underlies diseases such as sinusitis, otits and asthma. Different predisposing factors including immunological and non-immunological factors contribute to the disease pathogenesis. Objective: To investigate association of haptoglobin (Hp) phenotypes (Hp1-1, 2-1 and 2-2) with serum immunoglobulins A and E levels ...
متن کاملChildhood Obesity and Vascular Phenotypes
Methods A total of 6,576 children age 10 to 11 years from the ALSPAC (Avon Longitudinal Study of Parents and Children) were studied. Childhood overweight and obesity were based on body mass index contemporary to vascular measures and supported by other adiposity measures, including fat mass and waist circumference on dual-energy x-ray absorptiometry. Heart rate, blood pressure, flow-mediated di...
متن کاملRapid Testing of Gene-Gene Interactions in Genome-Wide Association Studies of Binary and Quantitative Phenotypes
Genome-wide association (GWA) studies have been extremely successful in identifying novel loci contributing effects to a wide range of complex human traits. However, despite this success, the joint marginal effects of these loci account for only a small proportion of the heritability of these traits. Interactions between variants in different loci are not typically modelled in traditional GWA a...
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ژورنال
عنوان ژورنال: Arteriosclerosis, Thrombosis, and Vascular Biology
سال: 2002
ISSN: 1079-5642,1524-4636
DOI: 10.1161/01.atv.0000024686.49995.41